Nitric Oxide Modulates Cardiac Na + Channel via Protein Kinase A and Protein Kinase G
نویسندگان
چکیده
منابع مشابه
Nitric oxide modulates cardiac Na(+) channel via protein kinase A and protein kinase G.
We directly tested the effects of nitric oxide (NO) on Na(+) channels in guinea pig and mouse ventricular myocytes using patch-clamp recordings. We have previously shown that NO donors have no observed effects on expressed Na(+) channels. In contrast, NO (half-blocking concentration of 523 nmol/L) significantly reduces peak whole-cell Na(+) current (I(Na)) in isolated ventricular myocytes. The ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/hh2301.100801